It is alittle weird at first but you get used to it
Im playing:
Super Street Fighter IV Arcade Edition
Legend of Zelda: Ocarina of Time
Legend of Zelda: Majora's Mask
Pokemon Stadium 2
Team Fortress 2
Fallout 3
I usually try to keep it at a max of two games per console.
Currently I'm playing:
Super Paper Mario (Wii)
Tiger Woods 12 (Wii)
Metro 2033 (360)
Legend of Zelda: Spirit Tracks (DS)
Evil Genius (PC)
Portal 2 (PC)
Although honestly most of my free time at the moment is being devoted to RPG Maker.